Anti-microbial, anti-inflammatory and anti-oxidant bioactivities of the methanolic extract of Alafia zambesiaca (stem-bark)

Alafia zambesiaca is a medicinal plant used widely in Ghana for the treatment of gastric/peptic ulcers. The objective this study was to comparatively assess effect methanolic and diethylether extracts phytochemicals on three bioactivities indicative ulcers etiology. Using standard laboratory assays involving broth dilution, carrageenan-induced foot swelling 7-day old chicks DPPH radical scavenging, compared contrasted antimicrobial, antioxidant anti-inflammatory extract with that diethyl ether stem-bark zambesiaca. Phytochemical analyses proffered mechanistic explanations differing solvent-specific by reporting presence tannins, flavonoids, saponins, glycosides triterpenoids demonstrating saponin only detectable phytochemical extract. more potent anti-oxidant vitro as demonstrated its relatively higher capacity, total phenolic content disproportionately lower IC50’s H2O2 assays. Consistently each panel four bacterial two fungal pathogenic microbial cell lines, showed anti-microbial activity recording, case, MICs were quantitatively than In vivo using carrageenan induced chick feet edema method indicated extract’s evocation dose-dependent reduction lack display measurable activity. Taken together, polar contains have qualitatively observation gives credence use aqueous ethnomedicinal management gastric mediates anti-ulcer effects mucosa possibly through phytochemical-triggered suppressive proliferation, via phytochemical-evoked mitigation concurrent cellular oxidative stress phytochemical-modulation inhibitory inflammatory events.